I think a Pokemon RPG where all the actual Pokemon stuff is almost the backdrop would be kind of cool. You'd be in the world and doing all your usual RPG stuff and occasionally you'd keep seeing this kid who's mother has just thrown him out into the world while she has affair after affair.
Your stories and travels would mirror each others so at the end while you fight the evil and save the world, the kid beats the elite four and gets all the fame, fortune and women while you come home with half your ear missing, a gammy leg and an unpaid mortgage.