I had it give me a disc read error the other day when I was loading from one area to another. It loads, then autosaves. It crashed before the autosave, and I lost 2 hours of play.
Then I went back and did those 2 hours again and I did everything differently. It's amazing that the whole "never the same experience twice" thing happens within only 2 hours of play.
And I think I'm nearing the end. It just gets better. But I have way too many resources. Full money almost constantly, high ammo and eve constantly. Playing through on Hard again should be alot better, assuming resources are more scarce rather than splicers just having more health.